2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-132116
    Biotin-PEG3-methyl ethanethioate
    Biotin-PEG3-methyl ethanethioate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG3-methyl ethanethioate
  • HY-140522
    2-(Azido-PEG3-amido)-1,3-bis(carboxylethoxy)propane 2086689-05-4
    2-Azido-PEG3-amido-13-biscarboxylethoxypropane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 2-(Azido-PEG3-amido)-1,3-bis(carboxylethoxy)propane is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    2-(Azido-PEG3-amido)-1,3-bis(carboxylethoxy)propane
  • HY-141312
    m-PEG5-phosphonic acid ethyl ester 1807512-42-0
    m-PEG5-phosphonic acid ethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG5-phosphonic acid ethyl ester
  • HY-120781
    Fluorescein-thiourea-PEG4-azide 1454662-54-4
    Fluorescein-thiourea-PEG4-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Fluorescein-thiourea-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Fluorescein-thiourea-PEG4-azide
  • HY-130886
    N3-PEG12-Hydrazide
    N3-PEG12-Hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N3-PEG12-Hydrazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N3-PEG12-Hydrazide
  • HY-175373
    Bispiperidin-piperazin-acetate
    Bispiperidin-piperazin-acetate is a PROTAC linker that can be used in the synthesis of PROTACs, such as PROTAC RIPK1 Degrader-1 (HY-175370).
    Bispiperidin-piperazin-acetate
  • HY-141193
    N-Boc-PEG12-alcohol 2218463-36-4
    N-Boc-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-Boc-PEG12-alcohol
  • HY-140599
    Propargyl-PEG4-S-PEG4-Boc 2055041-18-2
    Propargyl-PEG4-S-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG4-S-PEG4-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG4-S-PEG4-Boc
  • HY-132048
    Benzyl-PEG7-MS
    Benzyl-PEG7-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG7-MS
  • HY-133230
    Propargyl-PEG10-amine 2112737-25-2
    Propargyl-PEG10-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG10-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG10-amine
  • HY-140656D
    Biotin-PEG-Biotin (MW 5000)
    Biotin-PEG-Biotin (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG-Biotin (MW 5000)
  • HY-140703
    m-PEG-triethoxysilane (MW 2000)
    m-PEG-triethoxysilane (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG-triethoxysilane (MW 2000)
  • HY-133376
    DBCO-NHCO-PEG12-biotin 2621391-31-7
    DBCO-NHCO-PEG12-biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-NHCO-PEG12-biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-NHCO-PEG12-biotin
  • HY-141051
    N-(m-PEG9)-N'-(propargyl-PEG8)-Cy5 2107273-10-7
    N-(m-PEG9)-N'-(propargyl-PEG8)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(m-PEG9)-N'-(propargyl-PEG8)-Cy5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    N-(m-PEG9)-N'-(propargyl-PEG8)-Cy5
  • HY-W587352
    7-Iodohept-1-yne 87462-66-6
    7-Iodohept-1-yne is a PROTAC Linker that can be used to synthesize PROTAC QZ2135 (HY-170852).
    7-Iodohept-1-yne
  • HY-140751
    Benzyl-PEG5-MS 1807539-07-6
    Benzyl-PEG5-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG5-MS
  • HY-140989
    Mal-PEG1-bromide 1823885-81-9
    Mal-PEG1-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG1-bromide
  • HY-141197
    N-Boc-PEG23-bromide 2252157-01-8
    N-Boc-PEG23-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-Boc-PEG23-bromide
  • HY-141247
    1,1,1-Trifluoroethyl-PEG4-alcohol 1807512-41-9
    1,1,1-Trifluoroethyl-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    1,1,1-Trifluoroethyl-PEG4-alcohol
  • HY-132098
    Bis-propargyl-PEG10 1351373-48-2
    Bis-propargyl-PEG10 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bis-propargyl-PEG10 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Bis-propargyl-PEG10
PROTAC Linkers Isoform Comparison

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